Respiratory Epithelial Cells in Innate Immunity against Respiratory Viruses

Innate immunity in the lung: how epithelial cells ght against respiratory pathogens

Innate immunity in the lung: how epithelial cells ® ght against respiratory pathogens R Bals, P S Hiemstra #ERS Journals Ltd 2004 ABSTRACT: The human lung is exposed to a large number of airborne pathogens as a result of the daily inhalation of 10,000 litres of air The observation that respiratory infections are nevertheless rare is testimony to the presence of an ef® cient host defence system ...

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens.

The human lung is exposed to a large number of airborne pathogens as a result of the daily inhalation of 10,000 litres of air. The observation that respiratory infections are nevertheless rare is testimony to the presence of an efficient host defence system at the mucosal surface of the lung. The airway epithelium is strategically positioned at the interface with the environment, and thus plays...

Epithelial regulation of innate immunity to respiratory syncytial virus.

In the year 2001, we will mark the 45th anniversary of research on respiratory syncytial virus (RSV), the agent that was discovered as the cause of a “nosocomial outbreak” of colds in chimpanzees (1). Despite almost a half century of active clinical and basic investigations, an effective vaccine is still not available, and each year approximately 100,000 infants are hospitalized with RSV diseas...

Human Intestinal Epithelial Cells in Innate Immunity

RNA interference directs innate immunity against viruses in adult Drosophila.

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double...